Phase 2 · Closed beta · Computational proof-of-concept. Read what that means →
Protokol Lab/Use cases/Longevity & healthspan
For healthspan optimizers · Rapamycin · Metformin · Zone 2

Decades of compounding, modeled not guessed.

You're running rapamycin, NAD+, metformin, intentional Zone 2, sauna, ApoB-targeted nutrition. You're also stacking three interventions that all hit mTOR and ignoring the one that builds mitochondria. The lab maps your stack onto the actual pathways and tells you what's redundant.

4primary longevity pathways modeled
10-yrhorizon for chronic predictions
ApoB · hsCRP · HbA1c · IL-6tracked together
Conservativeit under-promises
01 / What keeps you up

The questions on the inside of your head — that aren't getting answered anywhere.

I built each of these models because I had the question and couldn't find an honest answer. Not from the prescriber. Not from the subreddit. Not from the AI summary that just regurgitated the prescriber.

01

Rapamycin every two weeks vs every week — the data does not exist for you.

It exists for mice. The lab won't pretend otherwise. It surfaces confidence bands, the studies they came from, and a "talk to your prescriber" card. Then it models the most-likely outcome for your ApoB and IL-6.

02

You're hitting mTOR from three angles and igniting AMPK from none.

Rapa + protein cycling + caloric restriction → all suppressing mTOR. Where's the mitochondrial biogenesis side? The lab decomposes every intervention into pathways and shows you where you're duplicating and where you're neglecting.

03

VO₂max is the strongest mortality predictor and you're training for the wrong thing.

Zone 2 builds mitochondrial density. Zone 5 builds VO₂max ceiling. Most people do neither. The lab models your weekly polarized split and projects 5-year VO₂max.

04

Cardiovascular events still kill ⅓ of you. ApoB is the actual lever.

Not LDL-C. ApoB. The lab targets < 60 mg/dL aggressively, models the response of every diet and lipid-lowering intervention, and won't let you forget the one biomarker that predicts the most.

02 / A real protocol

What the lab outputs for someone like you.

One real scenario someone built in the closed beta. Not a recommendation. A worked example — to show you the shape of what you'd be designing for yourself.

PROTOCOL · POLARIZED + RAPA + APOB-CONTROLLED

Rapamycin Q14d, metformin (T2D-trending only), ApoB-targeted lipidology, polarized cardio.

A 47-year-old beta user, ApoB starting at 102, hsCRP 1.4, fasting insulin 9. 12-month modeled outcome.

mTOR / AMPKRapamycin 6 mg Q14d (provider-led) · 16:8 TRF Mon–Fri
LIPIDSBempedoic acid 180 mg · 5 g EPA · ApoB target < 60
CARDIO3× Zone 2 (45m HR 130) + 1× VO₂max intervals (4x4)
STRENGTHTwice-weekly. Compound lifts. Bone + muscle insurance.
MONITORApoB · hsCRP · HbA1c · IL-6 · VO₂max · DEXA · LP(a)
HARM RULESStop rapa if hsCRP > 3 · skip if any infection
Not medical advice · Provider in the loop · Reviewed Q4W
PREDICTED SIGNALS · 12-WK1D7D12W
ApoB82 → 58 mg/dL
hsCRP1.4 → 0.6
HbA1c5.4 → 5.1
VO₂max42 → 47
Fasting insulin9 → 5.5
Visceral fat−18%
Bone density+1.4%
Biological age (proxy)−2.1 yr
03 / Bloodwork that matters

The tests that move this protocol — and why.

Not every marker on a Function Health panel matters for what you're doing. These are the ones that do, with the reason next to each.

ApoB
Quest · LabCorp
The single best CVD biomarker. Quarterly.
hsCRP
Quest · Function
Inflammation. Spikes catch overtraining and infection.
LP(a)
Quest · LabCorp
Once. Genetic. Changes the rest of the protocol.
HOMA-IR
Quest · Function
Insulin resistance. Earlier than HbA1c.
VO₂max
Lab · Garmin estimate
Strongest mortality predictor. Twice yearly.
DEXA + bone density
BodySpec
Body comp + osteoporosis hedge.
04 / Harm reduction

When the lab will refuse to model.

The harm engine is hard-coded, not statistical. MAOIs + SSRIs, methylene blue + serotonergics, contraindicated peptide stacks, dosing into a known drug-interaction window — the lab refuses to render the prediction and surfaces peer-reviewed warnings instead.

It will also flag when you're outside the population the literature was sampled from — pregnant, breastfeeding, under 18, or stacking peptides or supplements the model has low confidence in. You always know what the model knows and what it's guessing.

05 / With your provider

A protocol your prescriber will read.

Every protocol you save can be exported as a clean PDF: mechanisms cited, doses listed, comparator scenario attached, predicted markers tracked. The point isn't to replace your prescriber. The point is to walk into a 12-minute appointment with a structured artifact instead of a story.

This is not medical advice. By design. It is education that makes you a more informed person sitting across from someone who can give it.

Invite-only beta

Run the experiment before you run it on yourself.

Closed beta. Tell us you're building a routine for longevity & healthspan and we'll get you in. Every founder@ email gets read.